Multifunctional graphene-based magnetic nanocarriers for combined hyperthermia and dual stimuli-responsive drug delivery

• Tipo: Artigo em Revista Científica Internacional
• Data: 2018

Autores

Adrián M. T. Silva (Autor) FEUP; Raquel O. Rodrigues (Autor) FEUP; Giovanni Baldi (Autor) Outra; Saer Doumett (Autor) Outra; Lorena Garcia-Hevia (Autor) Outra; Juan Gallo (Autor) Outra; Manuel Bañobre-López (Autor) Outra; Goran Drazic (Autor) Outra; Ricardo C. Calhelha (Autor) Outra; Isabel C. F. R. Ferreira (Autor) Outra; Rui Lima (Autor) Outra; Helder T. Gomes (Autor) Outra

Revista

Título: Materials Science and Engineering C

Vol. 93

Páginas: 206-217

ISSN: 0928-4931

Editora: Elsevier

Indexação

ISI Web of Knowledge - 6 Citações

ISI Web of Science

Scopus - 33 Citações

INSPEC

Classificação Científica

CORDIS: Ciências Tecnológicas

Outras Informações

ID Authenticus: P-00P-DZE

DOI: 10.1016/j.msec.2018.07.060

Abstract (EN): The synthesis of hydrophilic graphene-based yolk-shell magnetic nanoparticles functionalized with copolymer pluronic F-127 (GYSMNP@PF127) is herein reported to achieve an efficient multifunctional biomedical system for mild hyperthermia and stimuli-responsive drug delivery. In vitro tests revealed the extraordinary ability of GYSMNP@PF127 to act as smart stimuli-responsive multifunctional nanomedicine platform for cancer therapy, exhibiting (i) an outstanding loading capacity of 91% (w/w, representing 910 mu g mg(-1)) of the chemotherapeutic drug doxorubicin, (ii) a high heating efficiency under an alternating (AC) magnetic field (intrinsic power loss ranging from 2.1-2.7 nHm(2) kg(-1)), and (iii) a dual pH and thermal stimuli-responsive drug controlled release (46% at acidic tumour pH vs 7% at physiological pH) under AC magnetic field, in just 30 (nth. Additionally, GYSMNP@PF127 presents optimal hydrodynamic diameter (D-H = 180 mn) with negative surface charge, high haemocompatibility for blood stream applications and tumour cellular uptake of drug nanocarriers. Due to its physicochemical, magnetic and biocompatibility properties, the developed graphene-based magnetic nano carrier shows high promise as dual exogenous (AC field)/endogenous (pH) stimuli-responsive actuators for targeted thermo-chemotherapy, combining magnetic hyperthermia and controlled drug release triggered by the abnormal tumour environment. The presented strategy and findings can represent a new way to design and develop highly stable added-value graphene-based nanostructures for the combined treatment of cancer.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 12