Epigallocatechin Gallate Nanodelivery Systems for Cancer Therapy

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2016

Autores

Granja, A (Autor) Outra; Pinheiro, M (Autor) Outra; Salette Reis (Autor) FFUP

Revista

Título: Nutrients

Vol. 8 Nº 770

Página Final: 307

ISSN: 2072-6643

Editora: MDPI

Indexação

ISI Web of Knowledge - 34 Citações

Scopus - 57 Citações

Outras Informações

ID Authenticus: P-00K-FV7

DOI: 10.3390/nu8050307

Abstract (EN): Cancer is one of the leading causes of morbidity and mortality all over the world. Conventional treatments, such as chemotherapy, are generally expensive, highly toxic and lack efficiency. Cancer chemoprevention using phytochemicals is emerging as a promising approach for the treatment of early carcinogenic processes. (-)-Epigallocatechin-3-gallate (EGCG) is the major bioactive constituent in green tea with numerous health benefits including anti-cancer activity, which has been intensively studied. Besides its potential for chemoprevention, EGCG has also been shown to synergize with common anti-cancer agents, which makes it a suitable adjuvant in chemotherapy. However, limitations in terms of stability and bioavailability have hampered its application in clinical settings. Nanotechnology may have an important role in improving the pharmacokinetic and pharmacodynamics of EGCG. Indeed, several studies have already reported the use of nanoparticles as delivery vehicles of EGCG for cancer therapy. The aim of this article is to discuss the EGCG molecule and its associated health benefits, particularly its anti-cancer activity and provide an overview of the studies that have employed nanotechnology strategies to enhance EGCG's properties and potentiate its anti-tumoral activity.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 23