Targeted macrophages delivery of rifampicin-loaded lipid nanoparticles to improve tuberculosis treatment

• Tipo: Artigo em Revista Científica Internacional
• Data: 2017

Autores

Vieira, ACC (Autor) Outra; Magalhaes, J (Autor) Outra; Rocha, S (Autor) Outra; Cardoso, MS (Autor) Outra; Santos, SG (Autor) Outra; Margarida Borges (Autor) FFUP; Pinheiro, M (Autor) Outra; Salette Reis (Autor) FFUP

Revista

Título: Nanomedicine

Vol. 12

Páginas: 2721-2736

ISSN: 1743-5889

Editora: Future Medicine Ltd.

Indexação

ISI Web of Knowledge - 7 Citações

Scopus - 25 Citações

Outras Informações

ID Authenticus: P-00N-8TA

DOI: 10.2217/nnm-2017-0248

Abstract (EN): Aim: This work aims to develop a mannosylated nanostructured lipid carrier (NLC) loaded with rifampicin to improve tuberculosis treatment. Materials & methods: An active targeting strategy was used and the nanoparticles were characterized. Effects on cell viability and the antimycobacterial activity of the nanoformulations were evaluated. Results: The nanoparticles developed exhibited a size of about 315 nm and polydispersity <0.2. The drug encapsulation efficiency was higher than 90% and its release was sensitive to pH. The mannosylated NLCs showed efficient uptake by bone marrow derived macrophages. Further, rifampicin-loaded mannosylated NLCs were more efficient in inducing a decrease of intracellular growth of mycobacteria. Conclusion: The NLCs developed can be used as a promising carrier for safer and efficient management of tuberculosis.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 16