Colorectal cancer and RASSF familyuA special emphasis on RASSF1A

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2013

Autores

Fernandes, MS (Autor) Outra; Carneiro F (Autor) FMUP; Oliveira C (Autor) FMUP; Seruca, R (Autor) FMUP

Revista

Título: International Journal of Cancer

Vol. 132

Páginas: 251-258

ISSN: 0020-7136

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 53 Citações

Scopus - 55 Citações

Outras Informações

ID Authenticus: P-002-18S

DOI: 10.1002/ijc.27696

Abstract (EN): The RAS-association domain family, commonly referred to as RASSF, is a family of 10 members (RASSF1-10) implicated in a variety of key biological processes, including cell cycle regulation, apoptosis and microtubule stability. Furthermore, RASSFs have been implicated in tumorigenesis and several family members are now thought to be tumor suppressors. As opposed to the KRAS oncogene, for which mutational activation is frequent in colorectal cancer (CRC), RASSFs are found to be silenced mainly by aberrant promoter methylation. In particular, RASSF1A, RASSF2 and RASSF5 methylation has been associated with CRC development, though the mechanisms of action remain poorly understood. This review focus on the current knowledge of RASSF inactivation in CRC, particularly RASSF1A, and on the implications RASSFs may have as potential biomarkers and for the development of new targeted therapies for CRC.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8