Patterns of expression of trefoil peptides and mucins in gastric polyps with and without malignant trans formation

• Tipo: Artigo em Revista Científica Internacional
• Data: 1999

Autores

Nogueira, AMMF (Autor) Outra; Machado JC (Autor) Outra; Carneiro F (Autor) FMUP; Celso Reis (Autor) Outra; Gott, P (Autor) Outra; Sobrinho Simoes, M (Autor) FMUP

Revista

Título: Journal of Pathology

Vol. 187

Páginas: 541-548

ISSN: 0022-3417

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 40 Citações

Scopus - 44 Citações

Outras Informações

ID Authenticus: P-001-4QX

DOI: 10.1002/(sici)1096-9896(199904)187:5<541::aid-path283>3.0.co;2-9

Abstract (EN): The expression of two trefoil peptides (TFF1 and TFF2) and four mucins (MUC1, MUC2, MUC5AC, and MUC6) was evaluated by inmunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR) in 29 gastric polyps, 10 hyperplastic and 19 adenomatous, eight of which displayed malignant transformation, The aims of this study were to characterize the expression profile of these molecules in each type of polyp and to investigate possible modifications of the profile during the process of malignant transformation, All hyperplastic polyps displayed immunoreactivity for TFF1, MUC5AC, and MUC1 in more than 75 per cent of the cells. In adenomatous polyps, three main phenotypes could be identified: complete gastric phenotype (co-expression of TFF1 and MUC5AC)-nine cases (47.4 per cent); incomplete gastric phenotype (TFF1-positive and MUC5AC-negative)-seven cases (36.8 per cent); non-gastric (intestinal) phenotype (no expression of TFF1 or MUC5AC)-three cases (15.8 per cent), Data yielded by immunohistochemistry and RT-PCR showed a good correlation for both TFF1 and TFF2, One hyperplastic and seven adenomatous polyps with villous architecture displayed foci of diffuse and intestinal-type carcinoma, respectively; in all of these cases, MUC1 expression and signs of gastric differentiation were observed in both the non-malignant and the carcinomatous component, It is concluded that gastric differentiation is a feature of hyperplastic polyps and of a subset of adenomatous polyps which is shared by early carcinomas arising in some of these polyps, regardless of the histological type of polyp and of carcinoma. Copyright (C) 1999 John Wiley & Sons, Ltd.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8