Identification of germ-line E-cadherin mutations in gastric cancer families of European origin

• Tipo: Artigo em Revista Científica Internacional
• Data: 1998

Autores

Gayther, SA (Autor) Outra; Gorringe, KL (Autor) Outra; Ramus, SJ (Autor) Outra; Huntsman, D (Autor) Outra; Roviello, F (Autor) Outra; Grehan, N (Autor) Outra; Machado JC (Autor) Outra; Pinto, E (Autor) Outra; Seruca, R (Autor) Outra; Halling, K (Autor) Outra; MacLeod, P (Autor) Outra; Powell, SM (Autor) Outra; Jackson, CE (Autor) Outra; Ponder, BAJ (Autor) Outra; Caldas, C (Autor) Outra

Revista

Título: Cancer Research

Vol. 58

Páginas: 4086-4089

ISSN: 0008-5472

Editora: American Association for Cancer Research

Indexação

ISI Web of Knowledge - 263 Citações

Scopus - 295 Citações

Outras Informações

ID Authenticus: P-001-72T

Abstract (EN): E-cadherin germ-line mutations have recently been described as a molecular basis for early-onset familial gastric cancer in Maori kindred. We screened 18 gastric cancer families of European origin for germ-line mutations to determine the proportion in which E-cadherin mutations occur and the clinical characteristics of the affected families. Truncating mutations were identified in three kindred with familial diffuse gastric cancer. In these families, the age of onset of gastric cancer was variable, the penetrance was incomplete, and one kindred contained individuals with cancers at other sites. Here, we show that a proportion of diffuse gastric cancer families of European origin have germ-line E-cadherin mutations; however, these mutations are absent in intestinal gastric cancer families.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 4