Pathophysiology of intestinal metaplasia of the stomach: emphasis on CDX2 regulation

• Tipo: Artigo em Revista Científica Internacional
• Data: 2010

Autores

Barros R (Autor) FMUP; Camilo, V (Autor) Outra; Pereira, B (Autor) Outra; Freund, JN (Autor) Outra; David L (Autor) FMUP; Raquel Almeida (Autor) FMUP

Revista

Título: Biochemical Society Transactions

Vol. 38

Páginas: 358-363

ISSN: 0300-5127

Editora: PORTLAND PRESS LTD

Indexação

ISI Web of Knowledge - 16 Citações

Scopus - 21 Citações

Outras Informações

ID Authenticus: P-003-7NH

DOI: 10.1042/bst0380358

Abstract (EN): IM (intestinal metaplasia) of the stomach is a pre-neoplastic lesion that usually follows Helicobacter pylori infection and that confers increased risk for gastric cancer development. After setting the role played by CDX2 (Caudal-type homeobox 2) in the establishment of gastric IM, it became of foremost importance to unravel the regulatory mechanisms behind its de novo expression in the stomach. In the present paper, we review the basic pathology of gastric IM as well as the current knowledge on molecular pathways involved in CDX2 regulation in the gastric context.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6