MICROSATELLITE INSTABILITY IS ASSOCIATED WITH TUMORS THAT CHARACTERIZE THE HEREDITARY NONPOLYPOSIS COLORECTAL-CARCINOMA SYNDROME

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 1993

Autores

PELTOMAKI, P (Autor) Outra; LOTHE, RA (Autor) Outra; AALTONEN, LA (Autor) Outra; PYLKKANEN, L (Autor) Outra; NYSTROMLAHTI, M (Autor) Outra; Seruca, R (Autor) Outra; David L (Autor) FMUP; HOLM, R (Autor) Outra; RYBERG, D (Autor) Outra; HAUGEN, A (Autor) Outra; BROGGER, A (Autor) Outra; BORRESEN, AL (Autor) Outra; DELACHAPELLE, A (Autor) Outra

Revista

Título: Cancer Research

Vol. 53

Páginas: 5853-5855

ISSN: 0008-5472

Editora: American Association for Cancer Research

Indexação

ISI Web of Knowledge - 592 Citações

Scopus - 589 Citações

Outras Informações

ID Authenticus: P-001-MBA

Abstract (EN): Microsatellite instability implying multiple replication errors (RER+ phenotype) characterizes a proportion of colorectal carcinomas, particularly those from patients with the hereditary non-polyposis colorectal carcinoma syndrome. We studied the incidence of microsatellite instability in more than 500 sporadic tumors representing 6 different types of cancer. Apart from colorectal carcinoma [see the paper by Lothe et al. (Cancer Res., 53: 5849-5852, 1993)] the RER+ phenotype was found in 18% (6 of 33) of gastric carcinomas and 22% (4 of 18) of endometrial carcinomas. In contrast, no evidence of this abnormality was detected in cancers of the lung (N = 85), breast (N = 84), and testis (N = 86). Importantly, the first three cancers, as opposed to the latter three, are characteristic of the hereditary non-polyposis colorectal carcinoma syndrome. These findings suggest that the cancers belonging to the hereditary non-polyposis colorectal carcinoma tumor spectrum may have essential pathogenetic steps in common, including a tendency to multiple replication errors.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 3