Limited role of the Toll-like receptor-2 in resistance to Mycobacterium avium

• Tipo: Artigo em Revista Científica Internacional
• Data: 2004

Autores

Gomes, MS (Autor) ICBAS; Florido, M (Autor) Outra; Cordeiro, JV (Autor) Outra; Teixeira, CM (Autor) Outra; Takeuchi, O (Autor) Outra; Akira, S (Autor) Outra; Appelberg, R (Autor) ICBAS

Revista

Título: Immunology

Vol. 111

Páginas: 179-185

ISSN: 0019-2805

Editora: Wiley-Blackwell

Indexação

Scopus - 28 Citações

Outras Informações

ID Authenticus: P-00H-V5W

DOI: 10.1111/j.0019-2805.2003.01807.x

Abstract (EN): The role of the Toll-like receptor (TLR)-2 in the generation of protective immunity to Mycobacterium avium was evaluated using gene-disrupted mice. TLR-2-/- mice were more susceptible than wild-type C57BI/6 mice to M. avium strains that were able to proliferate in vivo before the development of protective immunity and mycobacteriostasis. In contrast, the elimination of non-virulent strains was not affected by the mutation. The generation of interferon-¿ (IFN-¿)-producing T cells and the expression of the interleukin-12 p40 gene were reduced in TLR-2-deficient mice as compared to C57BI/6 mice early during infection with M. avium strain 2447. The generation of protective CD4+ T cells was also compromised in the mutated mice as compared with the controls. Our data show that TLR-2 is required for optimal immunity against certain virulent M. avium strains.

Idioma: Inglês

Tipo (Avaliação Docente): Científica