Discovery of Anti-Alzheimer Agents: Current Ligand-Based Approaches toward the Design of Acetylcholinesterase Inhibitors

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2012

Autores

Speck Planche, A (Autor) Outra; Luan, F (Autor) Outra; Cordeiro, MNDS (Autor) FCUP

Revista

Título: Mini-Reviews in Medicinal Chemistry

Vol. 12

Páginas: 583-591

ISSN: 1389-5575

Editora: Bentham Science

Indexação

ISI Web of Knowledge - 21 Citações

Scopus - 21 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-002-9B3

Abstract (EN): Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive dementia and loss of cognitive abilities. Until now, AD remains incurable. The principal biological target for AD therapy is acetylcholinesterase (AChE). Thus, the search for new drug candidates like AChE inhibitors constitutes an essential part for the discovery of more potent anti-AD agents. In general terms, rational drug design methodologies have played a decisive role. The present work is focused on the current state of the Ligand-Based Drug Design (LBDD) methods which have been applied to the elucidation of new molecular entities with high anti-AChE activity. Also, as a contribution to this field, we suggest a promising fragment-based approach for the search and prediction of new AChE inhibitors and for the fast and efficient extraction of substructural alerts which are responsible for the anti-AChE activity.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 9