ACIDITY CONSTANTS OF BILE-ACIDS IN AQUEOUS-SOLUTION UNDER PHYSIOLOGICAL CONDITIONS

• Tipo: Artigo em Revista Científica Internacional
• Data: 1994

Autores

DECASTRO, B (Autor) FCUP; LIMA, JLFC (Autor) FFUP; REIS, MSFFH (Autor) FFUP

Revista

Título: Analusis

Vol. 22

Páginas: 281-286

ISSN: 0365-4877

Editora: EDP Sciences

Indexação

ISI Web of Knowledge - 5 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Química

Outras Informações

ID Authenticus: P-001-JZ4

Abstract (EN): The acidity constants of cholic, deoxycholic, dehydrocholic, chenodeoxycholic and their glycine conjugates were determined potentiometrically in aqueous solution (I = 0.15 M NaCl) at several temperatures (10, 25 and 37-degrees-C), and at concentrations well below the critical micelle concentration; for glycocholic acid the acidity constant was also determined by IH nuclear magnetic resonance spectroscopy. The values obtained in this work are lower than those reported in the literature and an explanation for this observation is presented. The method developed in the present work allows for a fast and reliable determination of acidity constants of bile acids.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6