Synthesis of chlorinated flavonoids with anti-inflammatory and proapoptotic activities in human neutrophils

• Tipo: Artigo em Revista Científica Internacional
• Data: 2014

Autores

Marisa Freitas (Autor) Outra; Daniela Ribeiro (Autor) Outra; Sara M Tome (Autor) Outra; Artur M S Silva (Autor) Outra; Eduarda Fernandes (Autor) FFUP

Revista

Título: European Journal of Medicinal Chemistry

Vol. 86

Páginas: 153-164

ISSN: 0223-5234

Editora: Elsevier

Indexação

ISI Web of Knowledge - 23 Citações

Scopus - 34 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-009-RY4

DOI: 10.1016/j.ejmech.2014.08.035

Abstract (EN): Neutrophils are considered the central cells of acute inflammation. Flavonoids have been suggested as therapeutic agents to avoid damages induced by inflammatory processes. It is well known the reactivity of flavonoids with hypochlorous acid produced by neutrophils, to form stable mono and dichlorinated products. In this study, we synthesized novel chlorinated flavonoids and investigated their effect in neutrophils' oxidative burst and in its lifespan, in comparison with the parent non-chlorinated flavonoids. The obtained results demonstrate that chlorinated flavonoids were more efficient than their parent compounds in modulating neutrophils' oxidative burst in phorbol myristate acetate-activated neutrophils. Some of the tested flavonoids drive neutrophil apoptosis in a caspase 3-dependent fashion. The present data showed that 8-chloro-3',4',5,7-tetrahydroxyflavone (4a) constitute an alternative anti-inflammatory therapy, due to the proven ability to suppress mechanisms engaged at the onset and progression of inflammation.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 12