MACROPHAGE INFLAMMATORY PROTEINS MIP-1 AND MIP-2 ARE INVOLVED IN T-CELL-MEDIATED NEUTROPHIL RECRUITMENT

• Tipo: Artigo em Revista Científica Internacional
• Data: 1992

Autores

APPELBERG, R (Autor) ICBAS

Revista

Título: Journal of Leukocyte Biology

Vol. 52

Páginas: 303-306

ISSN: 0741-5400

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 64 Citações

Scopus - 58 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina clínica

Outras Informações

ID Authenticus: P-001-P79

Abstract (EN): Mice intraperitoneally (i.p.) infected with Mycobacterium bovis bacille Calmette-Guerin (BCG) respond to an i.p. challenge with mycobacterial antigen with an acute and extensive accumulation of neutrophils. This influx was not mimicked by the inoculation of recombinant interferon-gamma (IFN-gamma) or tumor necrosis factor alpha (TNF-alpha). The antigen-induced recruitment of neutrophils was not affected by coinoculation of anti-IFN-gamma antibodies, was enhanced by anti-TNF-alpha antisera, and was significantly reduced by antisera against macrophage inflammatory proteins MIP-1 and MIP-2. The latter two sera had no additive effects. We hypothesize that mycobacteria-specific T cells are triggered by antigen to secrete MIP-1 and MIP-2, which directly mediate, at least partly, the influx of neutrophils that takes place in this model.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 4