CRD-BP: A c-myc mRNA stabilizing protein with an oncofetal pattern of expression

• Tipo: Artigo em Revista Científica Internacional
• Data: 2003

Autores

Ioannidis, P (Autor) Outra; Mahaira, L (Autor) Outra; Papadopoulou, A (Autor) Outra; Manuel R Teixeira (Autor) ICBAS; Heim, S (Autor) Outra; Andersen, JA (Autor) Outra; Evangelou, E (Autor) Outra; Dafni, U (Autor) Outra; Pandis, N (Autor) Outra; Trangas, T (Autor) Outra

Revista

Título: Anticancer Research

Vol. 23

Páginas: 2179-2183

ISSN: 0250-7005

Editora: International Institute of Anticancer Research

Indexação

ISI Web of Knowledge - 24 Citações

Scopus - 27 Citações

Outras Informações

ID Authenticus: P-000-GQY

Abstract (EN): The Coding Region Determinant-Binding Protein (CRD-BP) is an RRM and KH-domain-containing protein that recognizes specifically at least three RNAs. It binds to one of the two c-myc mRNA instability elements, to the 5'Un Translated Region (UTR) of the leader 3 IGF-II mRNA and to the oncofetal H19 RNA. CRD-BP has been assigned a role in stabilizing c-myc mRNA by preventing its endonucleolytic cleavage and in repressing the translation of the leader 3 IGF-II mRNA, the major embryonic species of this message. CRD-BP is normally expressed only in fetal tissues. However, its expression is detected in primary tumors and transformed cell lines of different origins. The vast majority of colon (80%) and breast (60%) tumors and sarcomas (73%) express CRD-BP whereas in other tumor types, for example prostate carcinomas, its expression is rare. CRD-BP expression has also been detected in benign tumors such as breast fibroadenomas, meningiomas and other benign mesenchymal tumors, implying a role for this gene in abnormal cell proliferation. In breast carcinomas, CRD-BP expression and or gene copy number gains in the region encompassing the c-myc locus were detected in approximately 75% of tumors. implying that the deregulated expression of c-myc may be more widespread than previously believed. Infiltrated lymph nodes, corresponding to CRD-BP- positive primary tumors, were also found positive indicating that monitoring for CRD-BP could prove useful for the detection and monitoring of disseminated disease.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5