BP-M345, a New Diarylpentanoid with Promising Antimitotic Activity

• Tipo: Artigo em Revista Científica Internacional
• Data: 2021

Autores

Novais, P (Autor) Outra; Silva, PMA (Autor) Outra; Moreira, J (Autor) Outra; Palmeira, A (Autor) FFUP; Maria Isabel Amorim (Autor) FCUP; Pinto, M (Autor) Outra; Honorina Cidade (Autor) FFUP; Bousbaa, H (Autor) Outra

Revista

Título: Molecules

Vol. 19

Página Final: 7139

ISSN: 1420-3049

Editora: MDPI

Indexação

ISI Web of Knowledge - 1 Citação

Scopus - 2 Citações

Outras Informações

ID Authenticus: P-00V-RJC

DOI: 10.3390/molecules26237139

Abstract (EN): Previously, we reported the in vitro growth inhibitory effect of diarylpentanoid BP-M345 on human cancer cells. Nevertheless, at that time, the cellular mechanism through which BP-M345 exerts its growth inhibitory effect remained to be explored. In the present work, we report its mechanism of action on cancer cells. The compound exhibits a potent tumor growth inhibitory activity with high selectivity index. Mechanistically, it induces perturbation of the spindles through microtubule instability. As a consequence, treated cells exhibit irreversible defects in chromosome congression during mitosis, which induce a prolonged spindle assembly checkpoint-dependent mitotic arrest, followed by massive apoptosis, as revealed by live cell imaging. Collectively, the results indicate that the diarylpentanoid BP-M345 exerts its antiproliferative activity by inhibiting mitosis through microtubule perturbation and causing cancer cell death, thereby highlighting its potential as antitumor agent.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 20