HIV and HPV infections and ocular surface squamous neoplasia: systematic review and meta-analysis

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2013

Autores

Carreira, H (Autor) Outra; Coutinho, F (Autor) Outra; Carrilho, C (Autor) Outra; Lunet N (Autor) FMUP

Revista

Título: British Journal of Cancer

Vol. 109

Páginas: 1981-1988

ISSN: 0007-0920

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 42 Citações

Scopus - 48 Citações

Outras Informações

ID Authenticus: P-006-6SR

DOI: 10.1038/bjc.2013.539

Abstract (EN): Background: The frequency of ocular surface squamous neoplasias (OSSNs) has been increasing in populations with a high prevalence of infection with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) and infection with human papillomavirus (HPV). We aimed to quantify the association between HIV/AIDS and HPV infection and OSSN, through systematic review and meta-analysis. Methods: The articles providing data on the association between HIV/AIDS and/or HPV infection and OSSN were identified in MEDLINE, SCOPUS and EMBASE searched up to May 2013, and through backward citation tracking. The DerSimonian and Laird method was used to compute summary relative risk (RR) estimates and 95% confidence intervals (95% CI). Heterogeneity was quantified with the I-2 statistic. Results: HIV/AIDS was strongly associated with an increased risk of OSSN (summary RR = 8.06, 95% CI: 5.29-12.30, I-2 = 56.0%, 12 studies). The summary RR estimate for the infection with mucosal HPV subtypes was 3.13 (95% CI: 1.72-5.71, I-2 = 45.6%, 16 studies). Four studies addressed the association between both cutaneous and mucosal HPV subtypes and OSSN; the summary RR estimates were 3.52 (95% CI: 1.23-10.08, I-2 = 21.8%) and 1.08 (95% CI: 0.57-2.05, I-2 = 0.0%), respectively. Conclusion: Human immunodeficiency virus infection increases the risk of OSSN by nearly eight-fold. Regarding HPV infection, only the cutaneous subtypes seem to be a risk factor.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8