Living with sulfonamides: a diverse range of mechanisms observed in bacteria

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2020

Autores

Olga C Nunes (Autor) FEUP; Manaia, CM (Autor) Outra; Kolvenbach, BA (Autor) Outra; Corvini, PFX (Autor) Outra

Revista

Título: Applied Microbiology and Biotechnology

Vol. 104

ISSN: 0175-7598

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 1 Citação

Outras Informações

ID Authenticus: P-00T-1GQ

DOI: 10.1007/s00253-020-10982-5

Abstract (EN): Sulfonamides are the oldest class of synthetic antibiotics still in use in clinical and veterinary settings. The intensive utilization of sulfonamides has been leading to the widespread contamination of the environment with these xenobiotic compounds. Consequently, in addition to pathogens and commensals, also bacteria inhabiting a wide diversity of environmental compartments have been in contact with sulfonamides for almost 90 years. This review aims at giving an overview of the effect of sulfonamides on bacterial cells, including the strategies used by bacteria to cope with these bacteriostatic agents. These include mechanisms of antibiotic resistance, co-metabolic transformation, and partial or total mineralization of sulfonamides. Possible implications of these mechanisms on the ecosystems and dissemination of antibiotic resistance are also discussed.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 20