Rubella antibodies in cord blood sera in Portugal: association with maternal age and vaccination status

• Tipo: Artigo em Revista Científica Internacional
• Data: 2018

Autores

Frade, J (Autor) Outra; Nunes, C (Autor) Outra; Mesquita, JR (Autor) Outra; Nascimento, MSJ (Autor) FFUP; Goncalves, G (Autor) Outra

Revista

Título: Epidemiology and Infection

Vol. 146

Páginas: 600-605

ISSN: 0950-2688

Editora: Cambridge University Press

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 1 Citação

Outras Informações

ID Authenticus: P-00N-XAQ

DOI: 10.1017/s0950268818000237

Abstract (EN): This study evaluated the impact of maternal vaccination against rubella on the levels of specific rubella IgG (rIgG) in 198 newborn cord sera samples. Detailed maternal vaccination data were available. Specific rIgG was measured using a commercial enzyme immunoassay. Most mothers (78.8%) had been vaccinated against rubella at least once in their lives. In 15 (7.6%) cord sera samples, the concentration of specific rIgG was below 11 IU/ml, which was classified as seronegative. Statistical analysis using multiple logistic regression (n = 198) showed that newborns of mothers born between 1986 and 1995, and those born to unvaccinated mothers, were more likely to be seronegative (odds ratio (ORs) 5.2 and 4.9, respectively, adjusted for sex and gestational age). For vaccinated mothers (n = 156), those born between 1986 and 1995 were more likely to have seronegative newborns (OR 11.5 adjusting for sex, gestational age and time since last vaccination). Mothers of the 15 (7.6%) seronegative newborns might have been susceptible to rubella during pregnancy. Checking the vaccination status therefore recommended.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6