Gastric intestinal metaplasia revisited: function and regulation of CDX2

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2012

Autores

Barros R (Autor) FMUP; Freund, JN (Autor) Outra; David L (Autor) FMUP; Raquel Almeida (Autor) FMUP

Revista

Título: Trends in Molecular Medicine

Vol. 18

Páginas: 555-563

ISSN: 1471-4914

Editora: Elsevier

Indexação

ISI Web of Knowledge - 47 Citações

Scopus - 49 Citações

Outras Informações

ID Authenticus: P-002-641

DOI: 10.1016/j.molmed.2012.07.006

Abstract (EN): Intestinal metaplasia of the stomach is a preneoplastic lesion that appears following Helicobacter pylori infection and confers increased risk for gastric cancer development. However, the molecular networks connecting infection to lesion formation and the cellular origin of this lesion remain largely unknown. A more comprehensive understanding of how intestinal metaplasia arises and is maintained will be a major breakthrough towards developing novel therapeutic interventions. Furthermore, after ascertaining the pivotal role of CDX2 in establishing and maintaining intestinal metaplasia, it becomes important to decipher the upstream molecular pathways leading to its ectopic expression. Here, we review the pathophysiology of intestinal metaplasia in the context of the molecular network involved in its establishment and maintenance, with emphasis on CDX2 function and regulation.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 9