Driving chromosome segregation: lessons from the human and Drosophila centromere-kinetochore machinery

• Tipo: Artigo em Revista Científica Internacional
• Data: 2010

Autores

Orr, B (Autor) Outra; Afonso, O (Autor) Outra; Feijao, T (Autor) Outra; Sunkel, CE (Autor) ICBAS

Revista

Título: Biochemical Society Transactions

Vol. 38

Páginas: 1667-1675

ISSN: 0300-5127

Editora: PORTLAND PRESS LTD

Indexação

ISI Web of Knowledge - 4 Citações

Scopus - 4 Citações

Outras Informações

ID Authenticus: P-003-0BF

DOI: 10.1042/bst0381667

Abstract (EN): The kinetochore is a complex molecular machine that serves as the interface between sister chromatids and the mitotic pindle The kinetochore assembles at a particular chromosomal locus the centromere which is essential to maintain genomic stability during cell division The kinetochore is a macromolecular puzzle of subcomplexes assembled in a hierarchical manner and fulfils three main functions microtubule attachment chromosome and sister chromatid movement and regulation of mitotic progression though the spindle assembly checkpoint In the present paper we compare recent results on the assembly organization and function of the kinetochore in human and Drosophila cells and conclude that although essential functions are highly conserved there are important differences that might help define what is a minimal chromosome segregation machinery

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 9