Imunoterapia

Code:

OPT189

Acronym:

IMUNOT

Keywords
Classification	Keyword
OFICIAL	Medicine

Instance: 2020/2021 - 2S (of 08-02-2021 to 31-07-2021)

Active?	Yes
Responsible unit:	Departamento de Patologia
Course/CS Responsible:	Integrated Master in Medicine

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
MIMED	6	Mestrado Integrado em Medicina- Plano oficial 2013 (Reforma Curricular)	4	-	3	27	81
			5

Teaching language

Portuguese and english

Objectives

The student should acquire the following knowledge and competence 

1. The basic mechanism underlying immune-mediated diseases 
2. Principles of allergen immunotherapy ( Hymenoptera venom aeroallergens, food allergens) 
3. Using  immunotherapy and biologic treatments in immune-mediated diseases (allergic diseases, auto-immune disease and in cancer)  
4. Therapeutic approaches of primary immunodeficiencies  
5. Modulation of immune response using exercise and diet 

Learning outcomes and competences

1. Should identify indications and contra-indications for allergen immunotherapy and mechanisms involved


2. Understand the therapeutic aprroach in allergi, auto-immune and immunodeficiency disease


3. Understand the efficacy, safety and risk-benefit of immunotherapy


4. Interpret a case report and identify the most important recommended treatment options 


5. Present and publicly discuss a case report or a scientific paper showeing the immune-mediated mechanism and its therapeutic approach

Working method

Presencial

Program

Module 1: Aeroallergen Immunotherapy - treatment of allergic disease. 

Module 2: Food allergy immunotherapy - a new form of therapeutic approach, efficacy, safety and risk vs benefit. Short and long-term approach to the patient under food allergen immunotherapy 

Module 3: Biologicals as a new form therapeutic tool in immune-mediated diseases: asthma, rhinosinusitis, atopic dermatitis, food allergy and eosinophilic diseases 

Module 4: Therapeutic approach of primary immunodeficiencies 

Module 5: Immunotherapy in autoimmune diseases and cancer - new innovative pathways of treatment. 

Module 6: Exercise and diet as a form of non-pharmacological immunotherapy

Mandatory literature

EAACI; Allergen immunotherapy guidelines I and II 2017
Bonilla F et al; Practice parameter for the diagnosis and management of primary immunodeficiency, 2015
Fanouriakis A, Kostopoulou M, Alunno A, et al. 2019; Update of the EULAR recommendations for the management of systemic lupus erythematosus, 2019
Walsh NP, Gleeson M, Shephard RJ, et al; Position statement. Part one: Immune function and exercise, 2011

Teaching methods and learning activities

The Curricular Unit consists of a series of theoretical classes (8 sessions of 1 hour), seminar (2 sessions of 2.5 hours), theoretical-practical (6 sessions of 2.5 hours), corresponding to 28 contact hours, autonomous study (52h) and exam (1h) corresponding to a total of 81 hours and 3 credits in the European Credit Transfer and Accumulation System (ECTS). 

Assessment: Participation in theoretical and theoretical-practical classes, these will allow the discussion of applicability in the clinical practice of immunotherapy. The group presentation will also be included in the seminar of a clinical case seminars or a related scientific paper analysis. Students will be assessed individually for their performance in analyzing and discussing this case. 

Distributed evaluation with final exam.

 

Evaluation Type

Distributed evaluation with final exam

Assessment Components

Designation	Weight (%)
Apresentação/discussão de um trabalho científico	40,00
Exame	60,00
Total:	100,00

Amount of time allocated to each course unit

Designation	Time (hours)
Apresentação/discussão de um trabalho científico	5,00
Frequência das aulas	23,00
Estudo autónomo	53,00
Total:	81,00

Eligibility for exams

Distributed evaluation with final exam. Assessment component: 60% final exam; presentation work 40% 

To obtain frequency, it is necessary to attend at least 75% of the theoretical-practical classes and seminars 

Calculation formula of final grade

60% final exam; presentation work 40%