Cytogenetics and Cell Cycle

Code:

MI222

Acronym:

CCC

Keywords
Classification	Keyword
OFICIAL	Medicine

Instance: 2014/2015 - 1S

Active?	Yes
Responsible unit:	Genetics Department
Course/CS Responsible:	Integrated Master in Medicine

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
MIMED	243	Mestrado Integrado em Medicina- Plano oficial 2013 (Reforma Curricular)	2	-	3	25	81

Teaching language

Suitable for English-speaking students

Objectives

Acquire basic knowledge about: (A) cell cycle regulation, cell division and molecular processes underlying differentiation, dedifferentiation and cellular aging; (B) cytogenetic techniques and basic concepts on structure and function of chromosomes, (C) etiopathogenesis of chromosomal pathology, preparing students to acquire knowledge related to genetic transmission of chromosomal disorders and genetic risk assessment. Additionally it is intended that students be able to critically evaluate scientific literature and apply the basic principles of the scientific research in biology and genetics.

Learning outcomes and competences

The program integrates the fundamental knowledge of cell biology and genetics, to correlate the knowledge with clinical manifestations of genetic disorders namely the chromosomal pathology.

Working method

Presencial

Program

Cell cycle I - molecular regulation of interphase
Cell Cycle II - Mitosis
cellular aging
Apoptosis
Molecular Basis of Cancer
Meiotic division, gametes and fertilization
Chromosomes and chromosomal abnormalities of number and structure
Pathology of cell division and meiotic configurations
Cytogenetic techniques I
Cytogenetic techniques II
Chromosomal instability syndromes

Mandatory literature

Peter Turnpenny, Sian Ellard; Emery's Elements of Medical Genetics, Elsevier, 2012. ISBN: 9780702045059
Cooper, G.M. & Hausman; The Cell: A Molecular Approach , R.E. ASM Press, 2013. ISBN: 978-1-60535-155-1

Complementary Bibliography

Gardner, Sutherland and Shaffer; Chromosome abnormalities and genetic counseling , Oxford, 2012. ISBN: 9780195375336
Gersen and Keagle; The principles of clinical genetics , Humana Press, 2013. ISBN: 978-1-4419-1688-4
Pollard & Earnshaw; Cell Biology, Elsevier, 2007. ISBN: 978-1-4160-2255-8

Teaching methods and learning activities

Lectures (13hours) and laboratory sessions (12 hours).

Evaluation:

 1. Final assessment (95%) = ( theoretical evaluation + practical evaluation)

Part I – Theoretical component  - 30 multiple-choice questions/each 0.4 marks, quoted to 12 marks) + 20 true-false questions (each 0.15 marks, quoted to 3 marks); (Part I quoted to 15 marks)

Part II - Practical component - short answer questions (quoted to 5 marks): (Part II quoted to 5 marks

Students must reach a minimal classification of 9.5 (out of 20)

2. Evaluation of the student’s participation and attendance of in the teaching / learning of practical classes (5%)

keywords

Natural sciences > Biological sciences > Biology > Human biology
Health sciences
Natural sciences > Biological sciences > Biology > Genetics
Natural sciences > Biological sciences > Biology > Cell biology

Evaluation Type

Evaluation with final exam

Assessment Components

Designation	Weight (%)
Exame	95,00
Participação presencial	5,00
Total:	100,00

Calculation formula of final grade

Final assessment (95%) + Evaluation of the student’s participation and attendance (5%)


Part I – Theoretical component  - 30 multiple-choice questions/each 0.4 marks, quoted to 12 marks) + 20 true-false questions (each 0.15 marks, quoted to 3 marks); (Part I quoted to 15 marks)

Part II - Practical component - short answer questions (quoted to 5 marks)

Students must reach a minimal classification of 9.5 (out of 20)

Evaluation of the student’s participation and attendance of in the teaching / learning of practical classes (5%)(very good - 18-20 marks; good 14 a 17 marks; suficient 10 a 13 marks; insuficient - 0 marks)