Synthesis of chlorinated flavonoids with anti-inflammatory and proapoptotic activities in human neutrophils

• Type: Article in International Scientific Journal
• Date: 2014

Authors

Marisa Freitas (Author) Other; Daniela Ribeiro (Author) Other; Sara M Tome (Author) Other; Artur M S Silva (Author) Other; Eduarda Fernandes (Author) FFUP

Journal

Title: European Journal of Medicinal Chemistry

Vol. 86

Pages: 153-164

ISSN: 0223-5234

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 23 Citations

Scopus - 34 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-009-RY4

DOI: 10.1016/j.ejmech.2014.08.035

Abstract (EN): Neutrophils are considered the central cells of acute inflammation. Flavonoids have been suggested as therapeutic agents to avoid damages induced by inflammatory processes. It is well known the reactivity of flavonoids with hypochlorous acid produced by neutrophils, to form stable mono and dichlorinated products. In this study, we synthesized novel chlorinated flavonoids and investigated their effect in neutrophils' oxidative burst and in its lifespan, in comparison with the parent non-chlorinated flavonoids. The obtained results demonstrate that chlorinated flavonoids were more efficient than their parent compounds in modulating neutrophils' oxidative burst in phorbol myristate acetate-activated neutrophils. Some of the tested flavonoids drive neutrophil apoptosis in a caspase 3-dependent fashion. The present data showed that 8-chloro-3',4',5,7-tetrahydroxyflavone (4a) constitute an alternative anti-inflammatory therapy, due to the proven ability to suppress mechanisms engaged at the onset and progression of inflammation.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12