MACROPHAGE INFLAMMATORY PROTEINS MIP-1 AND MIP-2 ARE INVOLVED IN T-CELL-MEDIATED NEUTROPHIL RECRUITMENT

• Type: Article in International Scientific Journal
• Date: 1992

Authors

APPELBERG, R (Author) ICBAS

Journal

Title: Journal of Leukocyte Biology

Vol. 52

Pages: 303-306

ISSN: 0741-5400

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 64 Citations

Scopus - 58 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-001-P79

Abstract (EN): Mice intraperitoneally (i.p.) infected with Mycobacterium bovis bacille Calmette-Guerin (BCG) respond to an i.p. challenge with mycobacterial antigen with an acute and extensive accumulation of neutrophils. This influx was not mimicked by the inoculation of recombinant interferon-gamma (IFN-gamma) or tumor necrosis factor alpha (TNF-alpha). The antigen-induced recruitment of neutrophils was not affected by coinoculation of anti-IFN-gamma antibodies, was enhanced by anti-TNF-alpha antisera, and was significantly reduced by antisera against macrophage inflammatory proteins MIP-1 and MIP-2. The latter two sera had no additive effects. We hypothesize that mycobacteria-specific T cells are triggered by antigen to secrete MIP-1 and MIP-2, which directly mediate, at least partly, the influx of neutrophils that takes place in this model.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4