Novel beta-cyclodextrin modified CdTe quantum dots as fluorescence nanosensor for acetylsalicylic acid and metabolites

• Type: Article in International Scientific Journal
• Date: 2012

Authors

Algarra, M (Author) Other; Campos, BB (Author) Other; Aguiar, FR (Author) Other; Rodriguez Borges, JE (Author) FCUP; Esteves da Silva, JCGE (Author) FCUP

Journal

Title: Materials Science and Engineering C

Vol. 32

Pages: 799-803

ISSN: 0928-4931

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 20 Citations

Scopus - 21 Citations

Scientific classification

FOS: Engineering and technology > Materials engineering

Other information

Authenticus ID: P-002-AMA

DOI: 10.1016/j.msec.2012.01.028

Abstract (EN): beta-Cyclodextrin was modified with 11-[(ethoxycarbonyl)thio]undecanoic acid and used as a capping agent, together with mercaptosuccinic acid, to prepare water-stable CdTe quantum dots. The water soluble quantum dot obtained displays fluorescence with a maximum emission at 425 nm (under excitation at 300 nm) with lifetimes of 0.53, 4.8, 181, and 44.1 ns, respectively. The S-beta CD-MSA-CdTe can act as a nanoprobe that is due to the affinity of the cyclodextrin moiety for selected substances such as acetylsalicylic acid (ASA) and its metabolites as foreign species. The fluorescence of the S-beta CD-MSA-CdTe is enhanced on addition of ASA. Linear calibration plots are observed with ASA in concentrations between 0 and 1 mg/l, with a limit of detection at 8.5 x 10(-9) mol/1 (1.5 ng/ml) and a precision as relative standard deviation of 1% (0.05 mg/l). The interference effect of certain compounds as ascorbic acid and its main metabolites such as salicylic, gentisic and salicyluric acid upon the obtained procedure was studied.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5