CRD-BP: A c-myc mRNA stabilizing protein with an oncofetal pattern of expression

• Type: Article in International Scientific Journal
• Date: 2003

Authors

Ioannidis, P (Author) Other; Mahaira, L (Author) Other; Papadopoulou, A (Author) Other; Manuel R Teixeira (Author) ICBAS; Heim, S (Author) Other; Andersen, JA (Author) Other; Evangelou, E (Author) Other; Dafni, U (Author) Other; Pandis, N (Author) Other; Trangas, T (Author) Other

Journal

Title: Anticancer Research

Vol. 23

Pages: 2179-2183

ISSN: 0250-7005

Publisher: International Institute of Anticancer Research

Indexing

ISI Web of Knowledge - 24 Citations

Scopus - 27 Citations

Other information

Authenticus ID: P-000-GQY

Abstract (EN): The Coding Region Determinant-Binding Protein (CRD-BP) is an RRM and KH-domain-containing protein that recognizes specifically at least three RNAs. It binds to one of the two c-myc mRNA instability elements, to the 5'Un Translated Region (UTR) of the leader 3 IGF-II mRNA and to the oncofetal H19 RNA. CRD-BP has been assigned a role in stabilizing c-myc mRNA by preventing its endonucleolytic cleavage and in repressing the translation of the leader 3 IGF-II mRNA, the major embryonic species of this message. CRD-BP is normally expressed only in fetal tissues. However, its expression is detected in primary tumors and transformed cell lines of different origins. The vast majority of colon (80%) and breast (60%) tumors and sarcomas (73%) express CRD-BP whereas in other tumor types, for example prostate carcinomas, its expression is rare. CRD-BP expression has also been detected in benign tumors such as breast fibroadenomas, meningiomas and other benign mesenchymal tumors, implying a role for this gene in abnormal cell proliferation. In breast carcinomas, CRD-BP expression and or gene copy number gains in the region encompassing the c-myc locus were detected in approximately 75% of tumors. implying that the deregulated expression of c-myc may be more widespread than previously believed. Infiltrated lymph nodes, corresponding to CRD-BP- positive primary tumors, were also found positive indicating that monitoring for CRD-BP could prove useful for the detection and monitoring of disseminated disease.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5