BP-M345, a New Diarylpentanoid with Promising Antimitotic Activity

• Type: Article in International Scientific Journal
• Date: 2021

Authors

Novais, P (Author) Other; Silva, PMA (Author) Other; Moreira, J (Author) Other; Palmeira, A (Author) FFUP; Maria Isabel Amorim (Author) FCUP; Pinto, M (Author) Other; Honorina Cidade (Author) FFUP; Bousbaa, H (Author) Other

Journal

Title: Molecules

Vol. 19

Final page: 7139

ISSN: 1420-3049

Publisher: MDPI

Indexing

ISI Web of Knowledge - 1 Citation

Scopus - 2 Citations

Other information

Authenticus ID: P-00V-RJC

DOI: 10.3390/molecules26237139

Abstract (EN): Previously, we reported the in vitro growth inhibitory effect of diarylpentanoid BP-M345 on human cancer cells. Nevertheless, at that time, the cellular mechanism through which BP-M345 exerts its growth inhibitory effect remained to be explored. In the present work, we report its mechanism of action on cancer cells. The compound exhibits a potent tumor growth inhibitory activity with high selectivity index. Mechanistically, it induces perturbation of the spindles through microtubule instability. As a consequence, treated cells exhibit irreversible defects in chromosome congression during mitosis, which induce a prolonged spindle assembly checkpoint-dependent mitotic arrest, followed by massive apoptosis, as revealed by live cell imaging. Collectively, the results indicate that the diarylpentanoid BP-M345 exerts its antiproliferative activity by inhibiting mitosis through microtubule perturbation and causing cancer cell death, thereby highlighting its potential as antitumor agent.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 20