HIV and HPV infections and ocular surface squamous neoplasia: systematic review and meta-analysis

• Type: Another Publication in an International Scientific Journal
• Date: 2013

Authors

Carreira, H (Author) Other; Coutinho, F (Author) Other; Carrilho, C (Author) Other; Lunet N (Author) FMUP

Journal

Title: British Journal of Cancer

Vol. 109

Pages: 1981-1988

ISSN: 0007-0920

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 42 Citations

Scopus - 48 Citations

Other information

Authenticus ID: P-006-6SR

DOI: 10.1038/bjc.2013.539

Abstract (EN): Background: The frequency of ocular surface squamous neoplasias (OSSNs) has been increasing in populations with a high prevalence of infection with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) and infection with human papillomavirus (HPV). We aimed to quantify the association between HIV/AIDS and HPV infection and OSSN, through systematic review and meta-analysis. Methods: The articles providing data on the association between HIV/AIDS and/or HPV infection and OSSN were identified in MEDLINE, SCOPUS and EMBASE searched up to May 2013, and through backward citation tracking. The DerSimonian and Laird method was used to compute summary relative risk (RR) estimates and 95% confidence intervals (95% CI). Heterogeneity was quantified with the I-2 statistic. Results: HIV/AIDS was strongly associated with an increased risk of OSSN (summary RR = 8.06, 95% CI: 5.29-12.30, I-2 = 56.0%, 12 studies). The summary RR estimate for the infection with mucosal HPV subtypes was 3.13 (95% CI: 1.72-5.71, I-2 = 45.6%, 16 studies). Four studies addressed the association between both cutaneous and mucosal HPV subtypes and OSSN; the summary RR estimates were 3.52 (95% CI: 1.23-10.08, I-2 = 21.8%) and 1.08 (95% CI: 0.57-2.05, I-2 = 0.0%), respectively. Conclusion: Human immunodeficiency virus infection increases the risk of OSSN by nearly eight-fold. Regarding HPV infection, only the cutaneous subtypes seem to be a risk factor.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8