Rubella antibodies in cord blood sera in Portugal: association with maternal age and vaccination status

• Type: Article in International Scientific Journal
• Date: 2018

Authors

Frade, J (Author) Other; Nunes, C (Author) Other; Mesquita, JR (Author) Other; Nascimento, MSJ (Author) FFUP; Goncalves, G (Author) Other

Journal

Title: Epidemiology and Infection

Vol. 146

Pages: 600-605

ISSN: 0950-2688

Publisher: Cambridge University Press

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 1 Citation

Other information

Authenticus ID: P-00N-XAQ

DOI: 10.1017/s0950268818000237

Abstract (EN): This study evaluated the impact of maternal vaccination against rubella on the levels of specific rubella IgG (rIgG) in 198 newborn cord sera samples. Detailed maternal vaccination data were available. Specific rIgG was measured using a commercial enzyme immunoassay. Most mothers (78.8%) had been vaccinated against rubella at least once in their lives. In 15 (7.6%) cord sera samples, the concentration of specific rIgG was below 11 IU/ml, which was classified as seronegative. Statistical analysis using multiple logistic regression (n = 198) showed that newborns of mothers born between 1986 and 1995, and those born to unvaccinated mothers, were more likely to be seronegative (odds ratio (ORs) 5.2 and 4.9, respectively, adjusted for sex and gestational age). For vaccinated mothers (n = 156), those born between 1986 and 1995 were more likely to have seronegative newborns (OR 11.5 adjusting for sex, gestational age and time since last vaccination). Mothers of the 15 (7.6%) seronegative newborns might have been susceptible to rubella during pregnancy. Checking the vaccination status therefore recommended.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6