Gastric intestinal metaplasia revisited: function and regulation of CDX2

• Type: Another Publication in an International Scientific Journal
• Date: 2012

Authors

Barros R (Author) FMUP; Freund, JN (Author) Other; David L (Author) FMUP; Raquel Almeida (Author) FMUP

Journal

Title: Trends in Molecular Medicine

Vol. 18

Pages: 555-563

ISSN: 1471-4914

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 47 Citations

Scopus - 49 Citations

Other information

Authenticus ID: P-002-641

DOI: 10.1016/j.molmed.2012.07.006

Abstract (EN): Intestinal metaplasia of the stomach is a preneoplastic lesion that appears following Helicobacter pylori infection and confers increased risk for gastric cancer development. However, the molecular networks connecting infection to lesion formation and the cellular origin of this lesion remain largely unknown. A more comprehensive understanding of how intestinal metaplasia arises and is maintained will be a major breakthrough towards developing novel therapeutic interventions. Furthermore, after ascertaining the pivotal role of CDX2 in establishing and maintaining intestinal metaplasia, it becomes important to decipher the upstream molecular pathways leading to its ectopic expression. Here, we review the pathophysiology of intestinal metaplasia in the context of the molecular network involved in its establishment and maintenance, with emphasis on CDX2 function and regulation.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9