Driving chromosome segregation: lessons from the human and Drosophila centromere-kinetochore machinery

• Type: Article in International Scientific Journal
• Date: 2010

Authors

Orr, B (Author) Other; Afonso, O (Author) Other; Feijao, T (Author) Other; Sunkel, CE (Author) ICBAS

Journal

Title: Biochemical Society Transactions

Vol. 38

Pages: 1667-1675

ISSN: 0300-5127

Publisher: PORTLAND PRESS LTD

Indexing

ISI Web of Knowledge - 4 Citations

Scopus - 4 Citations

Other information

Authenticus ID: P-003-0BF

DOI: 10.1042/bst0381667

Abstract (EN): The kinetochore is a complex molecular machine that serves as the interface between sister chromatids and the mitotic pindle The kinetochore assembles at a particular chromosomal locus the centromere which is essential to maintain genomic stability during cell division The kinetochore is a macromolecular puzzle of subcomplexes assembled in a hierarchical manner and fulfils three main functions microtubule attachment chromosome and sister chromatid movement and regulation of mitotic progression though the spindle assembly checkpoint In the present paper we compare recent results on the assembly organization and function of the kinetochore in human and Drosophila cells and conclude that although essential functions are highly conserved there are important differences that might help define what is a minimal chromosome segregation machinery

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9