Occurrence of polycyclic aromatic hydrocarbon metabolites in urine of Portuguese firefighters

• Tipo: Artigo em Livro de Atas de Conferência Internacional
• Data: 2015

Autores

K. Slezakova (Autor) FEUP; M. Oliveira (Autor) Outra; A. Fernandes (Autor) Outra; J. A. Vaz (Autor) Outra; C. Delerue Matos (Autor) Outra; J. P. Teixeira (Autor) Outra; M. C. Pereira (Autor) FEUP; S. Morais (Autor) Outra

Ata de Conferência Internacional

Título: Proceedings of the 14th International Conference on Environmental Science and Technology (CEST2015)

Páginas: 2430-2434

Classificação Científica

CORDIS: Ciências Naturais > Ciências do ambiente

FOS: Ciências médicas e da saúde > Ciências da saúde

Projetos Associados

UI0511 - PROJECTO ESTRATÉGICO - UI 511 - 2013-2014

Outras Informações

Abstract (EN): The present work estimates occupational exposure of healthy and non-smoking Portuguese firefighters to polycyclic aromatic hydrocarbons (PAHs) through the analysis of four urinary metabolites (OH-PAHs): 1-hydroxyacenaphthene, 1-hydroxynaphthalene, 1-hydroxypyrene (PAH biomarker of exposure), and 3-hydroxybenzo[a]pyrene (PAH biomarker of carcinogenicity). Firemen from several Portuguese corporations were asked to provide urine samples during the winter period (without exposition to fires; pre-fire season) and during the summer season of 2014 after fires fighting. The selected OH-PAHs were extracted from urine samples by solid-phase extraction and analyzed by high-performance liquid chromatography with fluorescence detection. Normalization of the urinary PAH-metabolite levels was achieved by analyzing the creatinine concentrations. 1-hydroxynaphthalene and 1-hydroxyacenaphthene were the most abundant metabolites, followed by 1-hydroxypyrene. The metabolite 3- hydroxybenzo[a]pyrene was not detected. Total OH-PAHs ranged from 0.02 to 4.01 μmol/mol creatinine and between 0.55 to 8.39 μmol/mol creatinine, respectively, for non exposed and exposed firefighters. In general, the detected concentratio

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5