Occurrence of polycyclic aromatic hydrocarbon metabolites in urine of Portuguese firefighters

• Type: Article in International Conference Proceedings Book
• Date: 2015

Authors

K. Slezakova (Author) FEUP; M. Oliveira (Author) Other; A. Fernandes (Author) Other; J. A. Vaz (Author) Other; C. Delerue Matos (Author) Other; J. P. Teixeira (Author) Other; M. C. Pereira (Author) FEUP; S. Morais (Author) Other

Conference proceedings International

Title: Proceedings of the 14th International Conference on Environmental Science and Technology (CEST2015)

Pages: 2430-2434

Scientific classification

CORDIS: Natural sciences > Environmental science

FOS: Medical and Health sciences > Health sciences

Associated Projects

UI0511 - PROJECTO ESTRATÉGICO - UI 511 - 2013-2014

Other information

Abstract (EN): The present work estimates occupational exposure of healthy and non-smoking Portuguese firefighters to polycyclic aromatic hydrocarbons (PAHs) through the analysis of four urinary metabolites (OH-PAHs): 1-hydroxyacenaphthene, 1-hydroxynaphthalene, 1-hydroxypyrene (PAH biomarker of exposure), and 3-hydroxybenzo[a]pyrene (PAH biomarker of carcinogenicity). Firemen from several Portuguese corporations were asked to provide urine samples during the winter period (without exposition to fires; pre-fire season) and during the summer season of 2014 after fires fighting. The selected OH-PAHs were extracted from urine samples by solid-phase extraction and analyzed by high-performance liquid chromatography with fluorescence detection. Normalization of the urinary PAH-metabolite levels was achieved by analyzing the creatinine concentrations. 1-hydroxynaphthalene and 1-hydroxyacenaphthene were the most abundant metabolites, followed by 1-hydroxypyrene. The metabolite 3- hydroxybenzo[a]pyrene was not detected. Total OH-PAHs ranged from 0.02 to 4.01 μmol/mol creatinine and between 0.55 to 8.39 μmol/mol creatinine, respectively, for non exposed and exposed firefighters. In general, the detected concentratio

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5