Mapa das Instalações

Tânia R. Fernandes¹, Melani Mariscal Gómez², Antonio Serrano², Antonio Di Pietro²

¹ GreenUPorto – Research Centre on Sustainable Agrifood Production & DGAOT, Faculdade de Ciências da Universidade do Porto, Campus de Vairão, Rua da Agrária 747, 4485-646 Vairão, Portugal

²Departamento de Genetica, Universidad de Córdoba, 14071 Córdoba, Spain

pH is as a key player in the control of fungal pathogenicity. In the soilborne vascular wilt fungus Fusarium oxysporum, ambient pH acts as a master switch for regulation of a conserved MAPK cascade, essential for invasive growth and pathogenicity toward tomato roots. The molecular events underlying the pH response are currently unknown. We found that ambient pH modulates MAPK signaling by affecting intracellular pH (pHi) dynamics. Our results discover pHi as a new mechanism of signal transduction in fungi and reveal a complex interplay between signaling pathways and cellular functions in the regulation of MAPK signaling.