Interleukin-6 gene -174G > C and -636G > C promoter polymorphisms and prostate cancer risk

• Tipo: Artigo em Revista Científica Internacional
• Data: 2013

Autores

Magalhães JF (Autor) Outra; Cortinhas AJ (Autor) Outra; Albuquerque CM (Autor) Outra; Baptista CS (Autor) ICBAS; Ribeiro R (Autor) Outra; Viegas C (Autor) Outra; Matos AJ (Autor) ICBAS; Machado J (Autor) Outra; Pires MA (Autor) Outra; Guedes-Pinto H (Autor) Outra; Martins-Bessa A (Autor) Outra; Leitão JC (Autor) Outra; Bastos E (Autor) Outra

Revista

Título: Molecular Biology Reports

Vol. 40 Nº 1

Páginas: 449-455

ISSN: 0301-4851

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 12 Citações

ISI Web of Science

Scopus - 13 Citações

Pubmed / Medline

Classificação Científica

FOS: Ciências médicas e da saúde

Outras Informações

ID Authenticus: P-002-23H

DOI: 10.1007/s11033-012-2079-9

Abstract (EN): Prostate cancer (PCa) is one of the most commonly diagnosed internal malignancies affecting men. Due to the important roles of IL-6 in different physiological and pathophysiological processes, IL-6 polymorphisms may modulate PCa risk. IL-6 -174 G > C (rs 1800795, also designated -236 G > C) and -636 G > C (rs 1800796, also designated -572 G > C) promoter polymorphisms have been implicated in PCa susceptibility, albeit still controversial. A literature search using PubMed and Highwire databases was conducted, resulting in eight case-control studies concerning the IL-6 -174 G > C polymorphism (11,613 PCa cases and 13,992 controls) and four case-control publications regarding the IL-6 -636 G > C polymorphism (1,941 PCa cases and 3,357 controls). In order to derive a more precise estimation, a meta-analysis based upon these selected case-control studies was performed. There was no significant association between IL-6 -174 G > C polymorphism and PCa increased risk. Nevertheless, the presence of allele C and the CC genotype were statistically significantly associated with decreased PCa risk in the overall analysis for IL-6 -636 G > C polymorphism. Additional studies in larger samples and analyses of functional repercussions of these SNPs in prostate tumor cells are necessary to validate these findings.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7