Interleukin-6 gene -174G > C and -636G > C promoter polymorphisms and prostate cancer risk

• Type: Article in International Scientific Journal
• Date: 2013

Authors

Magalhães JF (Author) Other; Cortinhas AJ (Author) Other; Albuquerque CM (Author) Other; Baptista CS (Author) ICBAS; Ribeiro R (Author) Other; Viegas C (Author) Other; Matos AJ (Author) ICBAS; Machado J (Author) Other; Pires MA (Author) Other; Guedes-Pinto H (Author) Other; Martins-Bessa A (Author) Other; Leitão JC (Author) Other; Bastos E (Author) Other

Journal

Title: Molecular Biology Reports

Vol. 40 No. 1

Pages: 449-455

ISSN: 0301-4851

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 12 Citations

ISI Web of Science

Scopus - 13 Citations

Pubmed / Medline

Scientific classification

FOS: Medical and Health sciences

Other information

Authenticus ID: P-002-23H

DOI: 10.1007/s11033-012-2079-9

Abstract (EN): Prostate cancer (PCa) is one of the most commonly diagnosed internal malignancies affecting men. Due to the important roles of IL-6 in different physiological and pathophysiological processes, IL-6 polymorphisms may modulate PCa risk. IL-6 -174 G > C (rs 1800795, also designated -236 G > C) and -636 G > C (rs 1800796, also designated -572 G > C) promoter polymorphisms have been implicated in PCa susceptibility, albeit still controversial. A literature search using PubMed and Highwire databases was conducted, resulting in eight case-control studies concerning the IL-6 -174 G > C polymorphism (11,613 PCa cases and 13,992 controls) and four case-control publications regarding the IL-6 -636 G > C polymorphism (1,941 PCa cases and 3,357 controls). In order to derive a more precise estimation, a meta-analysis based upon these selected case-control studies was performed. There was no significant association between IL-6 -174 G > C polymorphism and PCa increased risk. Nevertheless, the presence of allele C and the CC genotype were statistically significantly associated with decreased PCa risk in the overall analysis for IL-6 -636 G > C polymorphism. Additional studies in larger samples and analyses of functional repercussions of these SNPs in prostate tumor cells are necessary to validate these findings.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7