Physiological, pathological and potential therapeutic roles of adipokines

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2012

Autores

Falcao Pires, I (Autor) FMUP; Castro-Chaves P (Autor) FMUP; Miranda Silva, D (Autor) Outra; Andre P Lourenco (Autor) FMUP; Leite-Moreira AF (Autor) FMUP

Revista

Título: Drug Discovery Today

Vol. 17

Páginas: 880-889

ISSN: 1359-6446

Editora: Elsevier

Indexação

ISI Web of Knowledge - 102 Citações

Scopus - 111 Citações

Outras Informações

ID Authenticus: P-002-74W

DOI: 10.1016/j.drudis.2012.04.007

Abstract (EN): Formerly regarded purely as passive energy storage, adipose tissue is now recognized as a vital endocrine organ. Adipocytes secrete diverse peptide hormones named adipokines, which act in a autocrine, paracrine or endocrine way to influence several biological functions. Adipokines comprise diverse bioactive substances, including cytokines, growth, and complement factors, which perform essential regulatory functions related to energy balance, satiety and immunity. Presently adipokines have been widely implicated in obesity, diabetes, hypertension and cardiovascular diseases. In this article we aim to present a brief description of the roles and potential therapeutic modulation of adipokines, such as leptin, resistin, adiponectin, apelin, visfatin, FABP-4, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 and plasminogen activator inhibitor-1 (PM-1).

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 10