Physiological, pathological and potential therapeutic roles of adipokines

• Type: Another Publication in an International Scientific Journal
• Date: 2012

Authors

Falcao Pires, I (Author) FMUP; Castro-Chaves P (Author) FMUP; Miranda Silva, D (Author) Other; Andre P Lourenco (Author) FMUP; Leite-Moreira AF (Author) FMUP

Journal

Title: Drug Discovery Today

Vol. 17

Pages: 880-889

ISSN: 1359-6446

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 102 Citations

Scopus - 111 Citations

Other information

Authenticus ID: P-002-74W

DOI: 10.1016/j.drudis.2012.04.007

Abstract (EN): Formerly regarded purely as passive energy storage, adipose tissue is now recognized as a vital endocrine organ. Adipocytes secrete diverse peptide hormones named adipokines, which act in a autocrine, paracrine or endocrine way to influence several biological functions. Adipokines comprise diverse bioactive substances, including cytokines, growth, and complement factors, which perform essential regulatory functions related to energy balance, satiety and immunity. Presently adipokines have been widely implicated in obesity, diabetes, hypertension and cardiovascular diseases. In this article we aim to present a brief description of the roles and potential therapeutic modulation of adipokines, such as leptin, resistin, adiponectin, apelin, visfatin, FABP-4, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 and plasminogen activator inhibitor-1 (PM-1).

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10