Current Status of Amino Acid-Based Permeation Enhancers in Transdermal Drug Delivery

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2021

Autores

Pereira, R (Autor) Outra; Silva, SG (Autor) Outra; Pinheiro, M (Autor) Outra; Reis, S (Autor) Outra; M. Luísa do Vale (Autor) FCUP; Sandra G. Silva (Autor) FCUP; Marina Pinheiro (Autor) FFUP

Revista

Título: Membranes

Vol. 11

Página Final: 343

ISSN: 2077-0375

Editora: MDPI

Indexação

ISI Web of Knowledge - 13 Citações

Scopus - 13 Citações

Classificação Científica

CORDIS: Ciências Físicas > Química > Química orgânica

Outras Informações

ID Authenticus: P-00T-WN2

DOI: 10.3390/membranes11050343

Abstract (EN): Transdermal drug delivery (TDD) presents many advantages compared to other conventional routes of drug administration, yet its full potential has not been achieved. The administration of drugs through the skin is hampered by the natural barrier properties of the skin, which results in poor permeation of most drugs. Several methods have been developed to overcome this limitation. One of the approaches to increase drug permeation and thus to enable TDD for a wider range of drugs consists in the use of chemical permeation enhancers (CPEs), compounds that interact with skin to ultimately increase drug flux. Amino acid derivatives show great potential as permeation enhancers, as they exhibit high biodegradability and low toxicity. Here we present an overview of amino acid derivatives investigated so far as CPEs for the delivery of hydrophilic and lipophilic drugs across the skin, focusing on the structural features which promote their enhancement capacity.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 22