Current Status of Amino Acid-Based Permeation Enhancers in Transdermal Drug Delivery

• Type: Another Publication in an International Scientific Journal
• Date: 2021

Authors

Pereira, R (Author) Other; Silva, SG (Author) Other; Pinheiro, M (Author) Other; Reis, S (Author) Other; M. Luísa do Vale (Author) FCUP; Sandra G. Silva (Author) FCUP; Marina Pinheiro (Author) FFUP

Journal

Title: Membranes

Vol. 11

Final page: 343

ISSN: 2077-0375

Publisher: MDPI

Indexing

ISI Web of Knowledge - 25 Citations

Scopus - 28 Citations

Scientific classification

CORDIS: Physical sciences > Chemistry > Organic chemistry

Other information

Authenticus ID: P-00T-WN2

DOI: 10.3390/membranes11050343

Abstract (EN): Transdermal drug delivery (TDD) presents many advantages compared to other conventional routes of drug administration, yet its full potential has not been achieved. The administration of drugs through the skin is hampered by the natural barrier properties of the skin, which results in poor permeation of most drugs. Several methods have been developed to overcome this limitation. One of the approaches to increase drug permeation and thus to enable TDD for a wider range of drugs consists in the use of chemical permeation enhancers (CPEs), compounds that interact with skin to ultimately increase drug flux. Amino acid derivatives show great potential as permeation enhancers, as they exhibit high biodegradability and low toxicity. Here we present an overview of amino acid derivatives investigated so far as CPEs for the delivery of hydrophilic and lipophilic drugs across the skin, focusing on the structural features which promote their enhancement capacity.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 22