Urocortins as biomarkers in cardiovascular disease

• Tipo: Artigo em Revista Científica Internacional
• Data: 2022

Autores

Vasconcelos, I (Autor) Outra; Adao, R (Autor) FMUP; Rademaker, MT (Autor) Outra; Leite Moreira, AF (Autor) Outra; Fontes Sousa, AP (Autor) Outra; Brás-Silva C (Autor) FMUP

Revista

Título: Clinical Science

Vol. 136

Páginas: 1-14

ISSN: 0143-5221

Editora: PORTLAND PRESS LTD

Indexação

ISI Web of Knowledge - 1 Citação

Scopus - 1 Citação

Outras Informações

ID Authenticus: P-00V-ZJD

DOI: 10.1042/cs20210732

Abstract (EN): The urocortins (Ucns) belong to the corticotropin-releasing factor (CRF) family of peptides and have multiple effects within the central nervous and the cardiovascular systems. With growing evidence indicating significant cardioprotective properties and cardiovascular actions of these peptides, the question arises as to whether the plasma profiles of the Ucns are altered in pathologic settings. While reports have shown conflicting results and findings have not been corroborated in multiple independent cohorts, it seems likely that plasma Ucn concentrations are elevated in multiple cardiovascular conditions. The degree of increase and accurate determination of circulating values of the Ucns requires further validation.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 14