Is there an ACE ID-ACTN3 R577X polymorphisms interaction that influences sprint performance?

• Tipo: Artigo em Revista Científica Internacional
• Data: 2009

Autores

N. Eynon (Autor) Outra; A. J. Alves (Autor) Outra; C. Yamin (Autor) Outra; M. Sagiv (Autor) Outra; J. A. Duarte (Autor) FADEUP; J. Oliveira (Autor) FADEUP; M. Ayalon (Autor) Outra; E. Goldhammer (Autor) Outra; M Sagiv (Autor) Outra; Y. Meckel (Autor) Outra

Revista

Título: International Journal of Sports Medicine

Vol. 30 Nº 12

Páginas: 888-891

ISSN: 0172-4622

Editora: Thieme

Indexação

ISI Web of Knowledge - 22 Citações

Scopus - 28 Citações

Pubmed / Medline

Classificação Científica

FOS: Ciências médicas e da saúde > Ciências da saúde

Outras Informações

ID Authenticus: P-003-DZB

DOI: 10.1055/s-0029-1238291

Abstract (EN): Functional R577X (rs.1815739) and ID (rs.5186) polymorphisms in the alpha-actinin-3 (ACTN3) and the angiotensin converting enzyme (ACE) genes, respectively, have been associated with sprint performance. The aim of this study was to determine their effect on sprint performance among 81 Israeli sprinters and 240 healthy controls. Results revealed that the ACE II genotype + ACTN3 R allele (P=0.003 for sprinters vs. controls), and the ACTN3 RR genotype+ACE I allele (P=0.001 for sprinters vs. controls) might be the genotype for sprinters. In the whole cohort the probability of ACTN3 RR genotype + ACE I allele being a sprinter (odds ratio 2.67, 95% confidence interval 1.45-4.93) and of ACE II genotype + ACFN3 R allele being a sprinter (odds ratio 3.57, 95% confidence interval 1.78-7.15) was significantly higher than that in the controls. in conclusion, the above data suggest that ACE ID/ACTN3 R577X genotype combination is associated with sprint ability. However, ACE ID/ACTN3 R577X genotype combination is not related to the level of performance.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 4