Novel cerium doped glass-reinforced hydroxyapatite with antibacterial and osteoconductive properties for bone tissue regeneration

• Tipo: Artigo em Revista Científica Internacional
• Data: 2015

Autores

Morais DS (Autor) FEUP; Fernandes S (Autor) Outra; Gomes PS (Autor) FMDUP; Fernandes MH (Autor) FMDUP; Sampaio P (Autor) Outra; Ferraz, MP (Autor) Outra; Santos, JD (Autor) FEUP; Maria Ascensão Lopes (Autor) FEUP; Sooraj Hussain N (Autor) Outra

Revista

Título: Biomedical Materials (Bristol)

Vol. 10 Nº 5

ISSN: 1748-6041

Editora: Institute of Physics Publishing

Indexação

ISI Web of Knowledge - 44 Citações

Scopus - 50 Citações

Pubmed / Medline

Classificação Científica

FOS: Ciências da engenharia e tecnologias > Engenharia médica

CORDIS: Ciências Tecnológicas > Engenharia > Engenharia biomédica ; Ciências Tecnológicas > Engenharia > Engenharia de materiais ; Ciências Tecnológicas > Engenharia > Engenharia de biomateriais

Outras Informações

ID Authenticus: P-00G-VZH

DOI: 10.1088/1748-6041/10/5/055008

Abstract (EN): The aim of this work was to develop a bioactive bone substitute with an effective antibacterial ability based on a cerium (Ce) doped glass-reinforced hydroxyapatite (GR-HA) composite. Developed composites were physicochemically characterized, using x-ray diffraction (XRD) analysis, SEM, energy dispersive x-ray spectroscopy (EDS), and flexural bending strength (FBS) tests. X-ray photoelectron spectroscopy (XPS) analysis was performed to analyze the oxidation state of Ce in the prepared doped glass. The antimicrobial activity of the composites was evaluated against Staphylococcus aureus, Staphylococcus epidermidis and Pseudomonas aeruginosa; whether the cytocompatibility profile was assayed with human osteoblastic-like cells (Mg-63 cell line). The results revealed that the Ce inclusion in the GR-HA matrix induced the antimicrobial ability of the composite. In addition, Ce-doped materials reported an adequate biological behavior following seeding of osteoblastic populations, by inducing cell adhesion and proliferation. Developed materials were also found to enhance the expression of osteoblastic-related genes. Overall, the developed GR-HA_Ce composite is a prospective candidate to be used within the clinical scenario with a successful performance due to the effective antibacterial properties and capability of enhancing the osteoblastic cell response.

Idioma: Inglês

Tipo (Avaliação Docente): Científica