Dynamic Cerebral Autoregulation Post Endovascular Thrombectomy in Acute Ischemic Stroke

• Tipo: Artigo em Revista Científica Internacional
• Data: 2020

Autores

Sheriff, F (Autor) Outra; Pedro Castro (Autor) FMUP; Kozberg, M (Autor) Outra; LaRose, S (Autor) Outra; Monk, A (Autor) Outra; Elsa Azevedo (Autor) FMUP; Li, K (Autor) Outra; Jafari, S (Autor) Outra; Rao, S (Autor) Outra; Otite, FO (Autor) Outra; Khawaja, A (Autor) Outra; Sorond, F (Autor) Outra; Feske, S (Autor) Outra; Ozan Tan, CO (Autor) Outra; Vaitkevicius, H (Autor) Outra

Revista

Título: Brain Sciences

Vol. 10 Nº 8, Article number 556

Páginas: 1-12

ISSN: 2076-3425

Editora: MDPI

Indexação

ISI Web of Knowledge - 21 Citações

Scopus - 18 Citações

Outras Informações

ID Authenticus: P-00S-QVB

DOI: 10.3390/brainsci10090641

Abstract (EN): The development of the endovascular thrombectomy (EVT) technique has revolutionized acute stroke management for patients with large vessel occlusions (LVOs). The impact of successful recanalization using an EVT on autoregulatory profiles is unknown. A more complete understanding of cerebral autoregulation in the context of EVT may assist with post-procedure hemodynamic optimization to prevent complications. We examined cerebral autoregulation in 107 patients with an LVO in the anterior circulation (proximal middle cerebral artery (M1/2) and internal cerebral artery (ICA) terminus) who had been treated using an EVT. Dynamic cerebral autoregulation was assessed at multiple time points, ranging from less than 24 h to 5 days following last seen well (LSW) time, using transcranial Doppler ultrasound recordings and transfer function analysis. Complete (Thrombolysis in Cerebral Infarction (TICI) 3) recanalization was associated with a more favorable autoregulation profile compared with TICI 2b or poorer recanalization (p< 0.05), which is an effect that was present after accounting for differences in the infarct volumes. Less effective autoregulation in the first 24 h following the LSW time was associated with increased rates of parenchymal hematoma types 1 and 2 hemorrhagic transformations (PH1-PH2). These data suggest that patients with incomplete recanalization and poor autoregulation (especially within the first 24 h post-LSW time) may warrant closer blood pressure monitoring and control in the first few days post ictus.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 13