Hydroxypropyl-beta-cyclodextrin-based fast dissolving carbamazepine printlets prepared by semisolid extrusion 3D printing

• Tipo: Artigo em Revista Científica Internacional
• Data: 2019-05-29

Autores

Jaime Conceição (Autor) FFUP; Xián Farto-Vaamonde (Autor) Outra; Alvaro Goyanes (Autor) Outra; Oluwatomide Adeoyed (Autor) Outra; Angel Concheiro (Autor) Outra; Helena Cabral-Marques (Autor) Outra; Sousa Lobo JM (Autor) FFUP; Carmen Alvarez-Lorenzo (Autor) Outra

Revista

Título: Carbohydrate Polymers

Vol. 221

Páginas: 55-62

ISSN: 0144-8617

Editora: Elsevier

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-00Q-QW7

DOI: 10.1016/j.carbpol.2019.05.084

Abstract (EN): This work aimed to explore for the first time the use of cyclodextrins to prepare printlets of poorly soluble drugs, such as carbamazepine, which require fine dose adjustment and rapid release. Orodispersible (flash) and immediate release formulations were 3D printed via semisolid extrusion of wet masses of hydroxypropyl-beta-cyclodextrin (HP beta CD) and cellulose ethers and regulating tablet porosity. Rheology of the wet masses allowed identifying printable compositions. Printing robustness was assessed evaluating weight, dimensions, hardness, drug content, and microstructure. Drug crystallinity, printlet disintegration and dissolution profiles were also characterized. The results highlight the feasibility of using HP beta CD as excipient in printlets of poorly soluble drugs, and the possibilities of tuning drug release profiles through small changes in cellulose ethers nature and ratio. Semisolid extrusion-based 3D printing is revealed as a feasible approach to in situ form carbamazepine-HP beta CD complexes and to produce printlets with suitable physical and drug release properties for oral delivery.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8