Farmacogenómica, Medicina de Precisão e Cidadania

Code:

OPT_MOM23_2

Acronym:

PDMOM23_2

Keywords
Classification	Keyword
OFICIAL	Medicine

Instance: 2024/2025 - SP

Active?	Yes
Responsible unit:	Departamento de Biomedicina
Course/CS Responsible:	Molecular Medicine and Oncology

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
PDMOM	9	Current Studies Plan	1	-	3	14	81

Teaching language

Suitable for English-speaking students

Objectives

General objective:

To present an advanced vision of Pharmacogenomics and its role in Precision and Personalized Medicine, as vectors for the individualization of treatments or chemoprevention, behavior change and encouragement of the practice of evidence-based medicine.

Particular objectives:

Theoretical review and discussion of current knowledge, with particular emphasis on its importance for the development of the skills of health professionals and for the understanding of appropriate strategies for Personalized and Precision Medicine.

Knowledge of the impact of new technologies in Precision Medicine and Pharmacogenomics, as enhancers of better diagnosis, earlier treatment and earlier disease prevention, taking into account individual variability: genetics, lifestyles and the environment.

 Recognition of Pharmacogenomics and Precision Medicine contribution to improve diagnostic efficacy and therapeutic guidance, resulting in the rational and efficient use of available resources and the improvement of clinical results (therapeutic efficacy/reduction of adverse effects). Genomics and the new concepts of citizenship.

Learning outcomes and competences

Students should be able to recognize up-to-date examples of the application of Pharmacogenomics to Personalized and Precision Medicine.

The use of examples with clinical relevance for humans and focused on the syllabus, prepares students for this professional challenge. Furthermore, in the case of doctors, pharmacists or other health professionals, alerts will be generated regarding new advances in the area and the scientific qualification for a scientifically based critical attitude.

The students will be encouraged to pay attention to conditions that may affect the effectiveness and toxicity of therapeutic procedures in order to minimize the associated risks during intervention.

Collaterally, awareness of equitable access to personalized healthcare, thus improving the promotion of citizenship, health literacy and active citizen participation.

Working method

Presencial

Program

- Introduction to the study of Pharmacogenomics and Precision Medicine. Its clinical evolution in the context of the evolution of Molecular Medicine, and its adaptation to new technologies.

- General concepts and the state of the art. Molecular Biology and Ecogenetics. Precision Medicine. Integrative Molecular Epidemiology: from risk assessment to prognosis.

- Basic aspects of Pharmacokinetics and Pharmacodynamics

- Biotransformation and Phase I and II Metabolism

- Genetic Polymorphisms as a study model in Pharmacogenomics. Polymorphisms in Phase I and II Metabolism Genes

- Other genetic models with application in Pharmacogenomics

- Applications of Pharmacogenomics in Preventive Medicine

- Applications of Pharmacogenomics in Oncology and other pathologies

- Pharmacogenomics and the development of new potential therapeutic targets

- Therapeutic and prognostic models: implications for pharmacogenomics.

- Viral models, molecular epidemiology and therapeutic strategies

- Bioinformatics and the new technologies in Pharmacogenomics and Precision Medicine.

- Importance of Pharmacogenomics and the Concept of Precision Medicine in the Teaching of Biomedical Sciences.

- Citizen participation in their health, promoting health literacy and personalized medicine.

- Clinical cases.

Mandatory literature

Yui-Wing Francis Lam Larisa Cavallari; Pharmacogenomics
Saulsberry L, Olopade OI.; Precision oncology: Directing genomics and pharmacogenomics toward reducing cancer inequities, Cancer Cell. 2021 Jun 14;39(6):730-733, 2021 (doi: 10.1016/j.ccell.2021.04.013)
Le-Niculescu H, Roseberry K, Gill SS, Levey DF, Phalen PL, Mullen J, Williams A, Bhairo S, Voegtline T, Davis H, Shekhar A, Kurian SM, Niculescu AB; Precision medicine for mood disorders: objective assessment, risk prediction, pharmacogenomics, and repurposed drugs, Mol Psychiatry. 2021 Apr 8. (doi: 10.1038/s41380-021-01061-w)
Kim JA, Ceccarelli R, Lu CY; Pharmacogenomic Biomarkers in US FDA-Approved Drug Labels (2000-2020), J Pers Med. 2021 Mar 4;11(3):179 (doi: 10.3390/jpm11030179)

Teaching methods and learning activities

Form of educational performance: Lecture with the presentation and discussion of relevant theoretical concepts in the classroom, self-study orientation of students by consulting annotated bibliography.
Seminars, Brainstorm on pertinent issues related to the matter exposed in the classroom. Written Evaluation.

Evaluation Type

Distributed evaluation with final exam

Assessment Components

Designation	Weight (%)
Exame	100,00
Total:	100,00

Amount of time allocated to each course unit

Designation	Time (hours)
Estudo autónomo	58,00
Frequência das aulas	23,00
Total:	81,00

Eligibility for exams

Presence in a minimum of 75% of classes.

Calculation formula of final grade

Without formula

Examinations or Special Assignments

To be evaluated