Molecular Cytogenetics II

Code:

OPT_MOM13_6

Acronym:

PDMOM13_6

Keywords
Classification	Keyword
OFICIAL	Medicine

Instance: 2024/2025 - SP

Active?	Yes
Responsible unit:	Departamento de Biomedicina
Course/CS Responsible:	Molecular Medicine and Oncology

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
PDMOM	5	Current Studies Plan	1	-	3	14	81

Teaching language

Suitable for English-speaking students

Objectives

To acquire knowledge about the various cytogenetic techniques; To know the advantages and limitations of these methodologies in various models of carcinogenesis; To understand the relevance of the genetic information for diagnosis, prognosis, treatment and follow up of neoplastic diseases; To know the somatic mutation theory of cancer, with emphasis for the relevance of fusion genes for carcinogenesis; Practical classes on FISH analysis.

Learning outcomes and competences

Acquisition of knowledge about the various cytogenetic techniques; Knowledge on the advantages and limitations of these methodologies in various models of carcinogenesis; Understading the relevance of the genetic information for diagnosis, prognosis, treatment and follow up of neoplastic diseases; Knowledge on the somatic mutation theory of cancer, with emphasis for the relevance of fusion genes for carcinogenesis.

Working method

Presencial

Program

1 - Historical perspective on the somatic mutation theory of cancer - The paradigmatic model of chronic myeloid leukemia.

2 - Relevance of cytogenetics in differential diagnosis - Examples in leukemias and sarcomas.

3 - Molecular subclassification with prognostic relevance - Examples of breast and prostate cancer.

4 - Molecular classification and targeted therapy in oncology - The lung cancer model.

5 - Clarification of doubts and exam.

Mandatory literature

Vários; Será disponibilizada no Moodle.

Comments from the literature

See Moodle; Given during classes

Teaching methods and learning activities

Theoretical lectures in classroom. Practical classes in the lab.

Theoretical lectures venue: EPOP, IPO-Porto (3rd floor, nearby the main auditorium).

keywords

Natural sciences > Biological sciences > Biology > Genetics
Health sciences > Medical sciences > Medicine > Oncology

Evaluation Type

Evaluation with final exam

Assessment Components

Designation	Weight (%)
Exame	100,00
Total:	100,00

Amount of time allocated to each course unit

Designation	Time (hours)
Estudo autónomo	54,00
Frequência das aulas	21,00
Total:	75,00

Eligibility for exams

Presence in 75% of the lectures.

Calculation formula of final grade

Mark on the final exame, 0-20.