Endocrine Pathology II

Code:

OPT_MOM13_11

Acronym:

PDMOM13_11

Keywords
Classification	Keyword
OFICIAL	Medicine

Instance: 2024/2025 - SP

Active?	Yes
Responsible unit:	Department of Medicine
Course/CS Responsible:	Molecular Medicine and Oncology

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
PDMOM	4	Current Studies Plan	1	-	3	14	81

Teaching language

Portuguese
Obs.: Português - Suitable for English-speaking students

Objectives

Space for the acquisition, debate and deepening of Endocrinology subjects, the all-time and the new ones topics, with emphasis on molecular diagnosis and the therapeutic molecular mechanisms.

Learning outcomes and competences

To get in depth knowledge in the fielf of: (i) endocrine disorders physiopathology understanding, with focus on the molecular mecanisms involved; (ii) molecular methods necessary to diagnosis establishments; (iii) molecular foundations of therapeutical issues.

Working method

B-learning

Pre-requirements (prior knowledge) and co-requirements (common knowledge)

Integrated Master course of Medicine and Pre-Bolonha Medicine graduation

Program

The adrenal cortex. Congenital adrenal hiperplasia. CYP 21 gene mutations.

A clinical case of Carney Complex. PRKAR1A mutations.

Multiple endocrine neoplasia. Insulinoma

Thyroid neoplasia  – New concepts. Familiar type of thyroid follicle epithelial carcinomas. Thyroid cancer epidemiology. Prognostic molecular markers of thyroid papillary crcinoma.

Adipose tissue. Lipodystrophies and intrathyroid lipomatosis. Genetic lypodistrophies.

Aquired lipodystrophies. Metabolic impact

Adrenal Medulla.

Familial paraganglioma. Familial types of pheocromocytoma and paragangliomas. DIPNECH

Autonomic Nervous system tumors diagnosis.

Diabetes Mellitus – Molecular markers of monogenic DM. Neonatal diabetes

MODY – Similarities and heterogeneities.

Type 1 diabetes

Pituitary tumours. Pathogenesis of pituitary tumors. Agressivity markers.

Mandatory literature

Shlomo Melmed, Ronald Koenig, Clifford Rosen, Richard Auchus, Allison Goldfine;; Textbook of Endocrinology

Complementary Bibliography

Oliveira SC, Neves JS, Pérez A, Carvalho D.; Maturity-onset diabetes of the young: From a molecular basis perspective toward the clinical phenotype and proper management.. ISBN: Endocrinol Diabetes Nutr. 2020 Feb;67(2):137-147.

Teaching methods and learning activities

Theoretical, tutorial orientation and seminars.

Evaluation Type

Evaluation with final exam

Assessment Components

Designation	Weight (%)
Exame	100,00
Total:	100,00

Amount of time allocated to each course unit

Designation	Time (hours)
Estudo autónomo	58,00
Frequência das aulas	23,00
Total:	81,00

Eligibility for exams

Presence in 75% of lectural activities.

Calculation formula of final grade

Without formula

Examinations or Special Assignments

No special work

Internship work/project

No project work

Special assessment (TE, DA, ...)

Yes

Classification improvement

Reevaluation