Therapeutics and Clinical Pharmacology II

Code:

MI542

Acronym:

TFC2

Keywords
Classification	Keyword
OFICIAL	Medicine

Instance: 2024/2025 - SP

Active?	Yes
Responsible unit:	Departamento de Biomedicina
Course/CS Responsible:	Integrated Master in Medicine

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
MIMED	264	Plano Oficial 2021	5	-	2	19	54

Teaching language

Portuguese and english

Objectives

To promote a critical understanding of medicines, from discovery to assessment and rational use.

This approach will both facilitate the acquisition and application of rules underlying the rational selection and prescription of drugs, as well as understanding the role of medical doctors in clinical pharmacology units, in regulatory agencies, in the pharmaceutical industry and in contract research organizations.

Therapeutics has an essentially formative background, aimed at the acquisition of skills to allow the correct use of drugs and also the practice of pedagogical interventions in health education. It is well known that patients´ education, and their relationship with therapeutics, has important outcomes in the improvement of compliance.

Learning outcomes and competences

At the end of this course unit the student should:

1. Know the general principles of Clinical Pharmacology and Therapeutics;
2. Be familiar with clinical pharmacology terminology;
3. Have developed observational skills;
4. Know the main therapeutic groups;
5. Have acquired a knowledge base that can be used in the various fields of therapeutics and applied later in other course units and in future clinical experience.

 

Students should also acquire the following competencies:

1. Problem-solving skills and practical application of knowledge;
2. Self-learning skills;
3. Critical reasoning;
4. Practical ability to evaluate therapeutic choices;
5. Identification of clinical pharmacology problems in selected clinical cases.

In order to provide students with the aforementioned skills and knowledge, this course unit will apply an integrated approach.

Working method

Presencial

Pre-requirements (prior knowledge) and co-requirements (common knowledge)

Knowledge of Medical Pharmacology that allow the development of clinical rationing with pharmacological therapeutic options.

Program

Structuring themes of Therapeutics and Clinical Pharmacology:

- Pharmacovigilance and toxicological aspects of medicines.

- Innovation in oncologic therapy.

Specific topics of Therapy addressed in integration with other curricular units:

Gastroenterology: peptic ulcer therapy and gastroesophageal reflux, therapy of inflammatory bowel disease.

Nephrology and Urology: therapy of low urinary tract dysfunctions and sexual dysfunctions (HBP, BH and ED), Medical therapy of kidney, prostate and urothelium neoplasms.

Oncological and Hematological diseases: Pharmacological therapy of neoplasms- general principles, Classical chemotherapy and cytostatic and cytotoxic therapy, Therapy of hemato-oncological diseases.

Gynecology and Obstetrics: Prescription of drugs in pregnant women, contraception, hormone replacement therapy and osteoporosis therapy, new pharmalogueic approaches in breast neoplasia therapy.

Psychiatry and Mental Health: Depression Therapy and Anxiety Therapy.

Clinical Epidemiology: Adverse drug reactions- how to report.

Legal Medicine: Therapeutic approach to acute intoxications.

Infectious diseases: Therapeutic approach to the patient with HIV infection/AIDS 

Anesthesiology and Intensive Care: Therapeutic approach to the patient with sepsis.

Aspects on the rational prescription of drugs taking into account the characteristics of the patient will be considered in the various pathologies, such as therapy in special populations; therapy in the elderly; therapy in the terminally ill patient; therapy in renal and hepatic insufficiency; therapy in pregnant women; therapy in the child.

Mandatory literature

Brunton, L.L., Hilal-Dandan, R. & Knollmann, B.C.; Goodman & Gilman’s The Pharmacological Basis of Therapeutics. ISBN: 978-1-25-958474-9

Complementary Bibliography

Katzung, B.G., & Trevor, A.J; Basic and Clinical Pharmacology. ISBN: 978-1-259-64115-2
Ritter, J.M., Flower, R.J., Henderson, G., Loke, Y.K. MacEawn D. & Rang, H; Rang and Dale’s Pharmacology. ISBN: 9780702074486
Guimarães, S., Moura, D., & Soares-da-Silva, P; Terapêutica medicamentosa e suas bases farmacológicas. ISBN: 978-972-0-01794-9

Teaching methods and learning activities

Teaching is based in theoretical and theoretical-practical classes.

The theoretical-practical classes involve prescription training accordingly to clinical cases and group discussion. Assessment is based on the acquisition of knowledge and decision-making skills.

Evaluation Type

Distributed evaluation with final exam

Assessment Components

Designation	Weight (%)
Participação presencial	50,00
Exame	50,00
Total:	100,00

Amount of time allocated to each course unit

Designation	Time (hours)
Estudo autónomo	35,00
Frequência das aulas	19,00
Total:	54,00

Eligibility for exams

It is mandatory to attend at least 75% of the planned teaching activities, with the exception of theoretical classes.

Calculation formula of final grade

The final classification will be done with 50% weighting in the distributed
assessment (AD) and 50% weighting in a written test (WT).



The classification for the distributed assessment is made taking into account:

a) Attendance

b) Active participation and individual resolution of clinical vignettes with a therapeutic plan in all theoretical-practical classes.



The written test has a maximum score of 20 values ​​and a minimum value of 10 values ​​is required to be included in the final weighting.



Final classification = (AD+WT)/2

Special assessment (TE, DA, ...)

According to the FMUP Pedagogical Regulation.

It should be noted that in the case of working students who are unable to take the distributed assessment, their final classification will be carried out only with the written test.

Classification improvement

Students can take an exam for classification improvement (at the time and dates according to the rules defined in the fmup pedagogical regulation). In these circumstances the final exam score is considered as final grade (the distributed evaluation is no longer considered).