Angiogenesis in inflammation and cancer I

Code:

MMOM13_7

Acronym:

MMOM13_7

Keywords
Classification	Keyword
OFICIAL	Medical and Molecular Oncology

Instance: 2023/2024 - SP

Active?	Yes
Responsible unit:	Departamento de Biomedicina
Course/CS Responsible:	Molecular Medicine and Oncology

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
MOM	15	Current Studies Plan	1	-	3	21	81

Teaching language

Portuguese
Obs.: Português (inglês caso haja estudantes de língua estrangeira)

Objectives

To understand the molecular mechanisms and the main factors involved in angiogenesis, as well as the angiogenic modulators (hypoxia, inflammation, oxidative stress, hormones, etc). To identify the role of angiogenesis in physiological and distinct pathological situations, particularly in cancer. To recognize methodologies used for examining angiogenesis (in vitro and in vivo models). To identify pro- and anti-angiogenic therapies.

 

The angiogenesis as a multistep process; processes that mediate angiogenesis, such as hypoxia, inflammation, oxidative stress, hormones, etc; the molecular mechanisms implicated, autocrine, paracrine and endocrine interactions involved in this process; and angiogenic imbalance in pathological situations, including cancer, but also other inflammatory disorders: diabetes and its vascular complications, cardiovascular disease. The role of radiotherapy in angiogenesis will be discussed. Pro- and anti-angiogenic therapies in clinical use will also be identified.

Learning outcomes and competences

The students are expected to obtain theoretical competencies and identify methodologies regarding the evaluation of angiogenesis in pathological situations. For example, to acknowledge angiogenesis as a multistep process;  angiogenic modulators, including hypoxia and inflammation, molecular mechanisms; autocrine, paracrine and endocrine interactions implicated in angiogenesis, and angiogenic imbalance in distinct  pathological conditions, such as cancer, diabetes, diabetic retinopathy, age-related macular degeneration, stroke and cardiovascular diseases. The role of radiotherapy in angiogenesis will be discussed. Pro- and antiangiogenic therapies used in the clinic will be described.

Working method

Presencial

Pre-requirements (prior knowledge) and co-requirements (common knowledge)

Basic knowledge regarding vascular biology.

Program

Introduction. Mechanisms of vascularization and signaling pathways

Angiogenic modulators: hypoxia; Inflammation

Methodologies for angiogenesis evaluation in vitro and in vivo

Pathological angiogenesis: a) Diabetic retinopathy, Retinopathy of the prematurity, AMD; b) Solid tumors c) Angiogenesis and radiotherapy; d) Stroke; e) systemic sclerosis; f) diabetes; acute myeloid leukemia;

Angiogenesis and tissue regeneration.
Angiogenesis and cancer metabolism

Anti-angiogenic and pro-angiogenic therapies.

Mandatory literature

Eelen G, de Zeeuw P, Simons M, Carmeliet P. ; Endothelial Cell Metabolism in Normal and Diseased Vasculature. , 2015
Costa C, Incio J, Soares R. ; Angiogenesis and Inflammation. Cause or consequence? , 2007
Cao Y, Langer R. ; A review of Judah Folkman's remarkable achievements in biomedicine., 2008

Complementary Bibliography

Soares R. ; Angiogenesis in metabolic syndrome, Springer-Verlag, The Netherlands, 2009
Carneiro A, Costa R, Falcao M, Mendonça L, Fonseca S, Gonçalves R, Falcao-Reis F, Soares R.; Vascular endothelial growth factor levels before and after treatment of neovascular age-related macular degeneration with bevacizumab and ranibizumab., 2012

Teaching methods and learning activities

Teaching methodologies: Lectures; Seminars; Paper revision (J Club);

Assessment: Writing/presenting a short monography on a subject regarding angiogenesis (e.g. angiogenesis in a particular disease, methodologies for evaluating angiogenesis, molecular signaling in angiogenesis, angiogenesis stimuli)

Type of assessment: distributed + Exam

 

Students must participate in a minimum of 75% of classes

Evaluation Formula: 0.80*exame + 0.20*Distributed evaluation

Evaluation Type

Distributed evaluation with final exam

Assessment Components

Designation	Weight (%)
Participação presencial	20,00
Trabalho escrito	40,00
Apresentação/discussão de um trabalho científico	40,00
Total:	100,00

Amount of time allocated to each course unit

Designation	Time (hours)
Trabalho escrito	20,00
Frequência das aulas	23,00
Apresentação/discussão de um trabalho científico	1,00
Total:	44,00

Eligibility for exams

Students must participate in a minimum of 75% of classes

Calculation formula of final grade

Evaluation Formula: 0.80*exame + 0.20*Distributed evaluation